Complement Factor I Antikörper (AA 19-300)

Produktnummer ABIN6138461

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Complement Factor I in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Complement Factor I Antikörper (AA 19-300) (ABIN6138461)

Target: Complement Factor I (CFI)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Complement Factor I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Complement Factor I Antikörper

Bindungsspezifität: AA 19-300

Sequenz: KVTYTSQEDL VEKKCLAKKY THLSCDKVFC QPWQRCIEGT CVCKLPYQCP KNGTAVCATN RRSFPTYCQQ KSLECLHPGT KFLNNGTCTA EGKFSVSLKH GNTDSEGIVE VKLVDQDKTM FICKSSWSMR EANVACLDLG FQQGADTQRR FKLSDLSINS TECLHVHCRG LETSLAECTF TKRRTMGYQD FADVVCYTQK ADSPMDDFFQ CVNGKYISQM KACDGINDCG DQSDELCCKA CQGKGFHCKS GVCIPSQYQC NGEVDCITGE DEVGCAGFAS VA

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human CFI (NP_000195.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Complement Factor I

Target: Complement Factor I (CFI)

Andere Bezeichnung: CFI

Hintergrund: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.,CFI,AHUS3,ARMD13,C3BINA,C3b-INA,FI,IF,KAF,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,CFI

Molekulargewicht: 65 kDa

Gen-ID: 3426

UniProt: P05156

Pathways: Komplementsystem