CD59 Antikörper (AA 26-128)

Produktnummer ABIN6138210

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CD59 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD59 Antikörper (AA 26-128) (ABIN6138210)

Target: CD59

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD59 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD59 Antikörper

Bindungsspezifität: AA 26-128

Sequenz: LQCYNCPNPT ADCKTAVNCS SDFDACLITK AGLQVYNKCW KFEHCNFNDV TTRLRENELT YYCCKKDLCN FNEQLENGGT SLSEKTVLLL VTPFLAAAWS LHP

Kreuzreaktivität: Human, Maus

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 26-128 of human CD59 (NP_001120695.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59

Hintergrund: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.,CD59,16.3A5,1F5,EJ16,EJ30,EL32,G344,HRF-20,HRF20,MAC-IP,MACIF,MEM43,MIC11,MIN1,MIN2,MIN3,MIRL,MSK21,p18-20,Signal Transduction,Kinase,Tyrosine kinases,Immunology & Inflammation,CD markers,Cell Intrinsic Innate Immunity Signaling Pathway,Stem Cells,Hematopoietic Progenitors,Cardiovascular,CD59

Molekulargewicht: 14 kDa

Gen-ID: 966

UniProt: P13987

Pathways: Komplementsystem