Calpain S1 Antikörper (AA 69-268)

Produktnummer ABIN6137928

Dieses Anti-Calpain S1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Calpain S1 in WB, IHC und IF. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Calpain S1 Antikörper (AA 69-268) (ABIN6137928)

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Calpain S1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Calpain S1 Antikörper

Bindungsspezifität: AA 69-268

Sequenz: ISEAAAQYNP EPPPPRTHYS NIEANESEEV RQFRRLFAQL AGDDMEVSAT ELMNILNKVV TRHPDLKTDG FGIDTCRSMV AVMDSDTTGK LGFEEFKYLW NNIKRWQAIY KQFDTDRSGT ICSSELPGAF EAAGFHLNEH LYNMIIRRYS DESGNMDFDN FISCLVRLDA MFRAFKSLDK DGTGQIQVNI QEWLQLTMYS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human Calpain small subunit 1 (NP_001740.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Kommentare:

HIGH QUALITY

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-Calpain S1 Antikörper (ABIN6137928)

Liu, Lou, Li, Xu, Ruan, Xiao, Qiu, Bao, Yuan, Huang, Wang, Cao, Chen, Yang, Zhang: "Calpain and AR-V7: Two potential therapeutic targets to overcome acquired docetaxel resistance in castration-resistant prostate cancer cells." in: Oncology reports, Vol. 37, Issue 6, pp. 3651-3659, (2018) (PubMed).

Details zu Calpain S1

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Andere Bezeichnung: CAPNS1

Hintergrund: This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.,CAPNS1,CALPAIN4,CANP,CANPS,CAPN4,CDPS,CSS1,Signal Transduction,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Neuroscience,Calcium Signaling,CAPNS1

Molekulargewicht: 28 kDa

Gen-ID: 826

UniProt: P04632

Pathways: Apoptose