MMP2 Antikörper

Produktnummer ABIN5958295

Dieses Anti-MMP2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MMP2 in WB, ELISA, IF und IHC (p). Geeignet für Human, Ratte, Maus und Affe.

Kurzübersicht für MMP2 Antikörper (ABIN5958295)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reaktivität: Human, Ratte, Maus, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-MMP2 Antikörper

Spezifität: 72 kDa gelatinase,72kD type IV collagenase,CLG 4,CLG 4A,CLG4,CLG4A,Collagenase Type 4 alpha,Collagenase type IV A,Gelatinase A,Gelatinase alpha,Gelatinase neutrophil,Matrix metallopeptidase 2 gelatinase A 72  kDa gelatinase 72  kDa type IV collagenase,Matrix metalloproteinase 2 (gelatinase A,72  kDa gelatinase,72  kDa type IV collagenase),Matrix Metalloproteinase 2,Matrix metalloproteinase II,Matrix metalloproteinase-2,MMP 2,MMP II,MMP-2,MMP2,MMP2,MONA,Neutrophil gelatinase,PEX,TBE 1,TBE-1

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from the C-terminal region of human MMP-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Andere Bezeichnung: MMP2

Hintergrund: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.

Molekulargewicht: 74kDa

Gen-ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response