TYK2 Antikörper (Tyr1054)

Produktnummer ABIN5957298

Der Kaninchen Polyklonal Anti-TYK2-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, TYK2 in Proben von Human, Maus und Affe zu detektieren.

Kurzübersicht für TYK2 Antikörper (Tyr1054) (ABIN5957298)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reaktivität: Human, Maus, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TYK2 Antikörper

Bindungsspezifität: Tyr1054

Spezifität: JTK 1,JTK1,Non receptor tyrosine protein kinase 2,Non receptor tyrosine protein kinase TYK2,Non-receptor tyrosine-protein kinase TYK2,OTTHUMP00000232745,OTTHUMP00000232746,OTTHUMP00000232748,Protein Tyrosine Kinase 2,TYK 2,Tyk2,TYK2,Tyrosine kinase 2

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Tyr1054.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Andere Bezeichnung: Tyk 2

Hintergrund: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Primary Cutaneous Anaplastic Large Cell Lymphoma. Among its related pathways are Type I Interferon Signaling Pathways and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.

Molekulargewicht: 134kDa

Gen-ID: 7297

UniProt: P29597

Pathways: JAK-STAT Signalweg, Hepatitis C