TYK2 Antikörper (Tyr1054)

Produktnummer ABIN5957298

Der Kaninchen Polyklonal anti-TYK2 Antikörper wird verwendet zum Nachweis von TYK2 in Proben von Human, Maus und Affe. Er wurde validiert für WB, ELISA, IF und IHC (p).

Kurzübersicht für TYK2 Antikörper (Tyr1054) (ABIN5957298)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reaktivität: Human, Maus, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TYK2 Antikörper

Bindungsspezifität: Tyr1054

Spezifität: JTK 1,JTK1,Non receptor tyrosine protein kinase 2,Non receptor tyrosine protein kinase TYK2,Non-receptor tyrosine-protein kinase TYK2,OTTHUMP00000232745,OTTHUMP00000232746,OTTHUMP00000232748,Protein Tyrosine Kinase 2,TYK 2,Tyk2,TYK2,Tyrosine kinase 2

Aufreinigung: Affinity purification

Immunogen: Synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Tyr1054.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol,  pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Andere Bezeichnung: Tyk 2

Hintergrund: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.TYK2 (Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with TYK2 include Immunodeficiency 35 and Primary Cutaneous Anaplastic Large Cell Lymphoma. Among its related pathways are Type I Interferon Signaling Pathways and Immune response IFN alpha/beta signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is JAK1.

Molekulargewicht: 134kDa

Gen-ID: 7297

UniProt: P29597

Pathways: JAK-STAT Signalweg, Hepatitis C