ABCE1 Antikörper (AA 419-599)

Produktnummer ABIN5708515

Der Kaninchen Polyklonal anti-ABCE1 Antikörper (ABIN5708515) detektiert spezifisch ABCE1 in WB, FACS, IF und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für ABCE1 Antikörper (AA 419-599) (ABIN5708515)

Target: ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-ABCE1 Antikörper

Bindungsspezifität: AA 419-599

Verwendungszweck: ABCE1 Antibody

Aufreinigung: Antigen affinity

Immunogen: Amino acids K419-D599 from the human protein were used as the immunogen for the ABCE1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Differences in protocols and secondary/substrate sensitivity may require the ABCE1 antibody to be titrated for optimal performance.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: After reconstitution, the ABCE1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Details zu ABCE1

Target: ABCE1 (RLI1) (ABC Transporter E Family Member 1 (RLI1))

Andere Bezeichnung: ABCE1 / ATP binding cassette E1

Hintergrund: ATP binding cassette E1 (ABCE1, also called RNase L inhibitor) is an ATPase found in humans involved in viral assembly. It is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumorcell proliferation and antiapoptosis.

UniProt: P61221