TNFSF15 Antikörper

Produktnummer ABIN5708012

Dieser Kaninchen Monoklonal Antikörper erkennt spezifisch TNFSF15 in IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TNFSF15 Antikörper (ABIN5708012)

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TNFSF15 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: VEGI-2052R

Produktdetails anti-TNFSF15 Antikörper

Aufreinigung: Purified

Reinheit: Protein A affinity chromatography

Immunogen: A full length human recombinant protein was used as the immunogen for this recombinant TNFSF15 antibody.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: Titration of the recombinant TNFSF15 antibody may be required for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL,Prediluted IHC only format : incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant TNFSF15 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu TNFSF15

Target: TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))

Andere Bezeichnung: TNFSF15 / VEGI / TL1A

Hintergrund: TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A/TNFSF15/VEGI has been reported as a marker of poor prognosis in breast cancer.

Gen-ID: 9966

Pathways: Positive Regulation of Endopeptidase Activity, Autophagie