Rekombinanter ISR-alpha Antikörper (Extracellular)

Produktnummer ABIN5707973

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch ISR-alpha in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter ISR-alpha Antikörper (Extracellular) (ABIN5707973)

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser ISR-alpha Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Güteklasse: Carrier-free

Klon: INSR-2277R

Produktdetails anti-ISR-alpha Antikörper

Bindungsspezifität: Extracellular

Verwendungszweck: Recombinant Insulin Receptor alpha Antibody (azide and preservative free)

Aufreinigung: Protein A affinity chromatography

Immunogen: A recombinant partial protein from the extracellular region of the protein was used as the immunogen for the recombinant Insulin Receptor alpha antibody.

Isotyp: IgG, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the recombinant Insulin Receptor alpha antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant Insulin Receptor alpha antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu ISR-alpha

Target: ISR-alpha (Insulin Receptor alpha (ISR-alpha))

Andere Bezeichnung: Insulin Receptor alpha

Hintergrund: The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular β, subunit and an extracellular α, subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

UniProt: P06213