Thyroglobulin Antikörper

Produktnummer ABIN5707705

Dieses Anti-Thyroglobulin-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von Thyroglobulin in IHC (p). Geeignet für Human und Ratte.

Kurzübersicht für Thyroglobulin Antikörper (ABIN5707705)

Target: Thyroglobulin (TG)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Thyroglobulin Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: TGB-1970R

Produktdetails anti-Thyroglobulin Antikörper

Kreuzreaktivität (Details): Not suitable for mouse

Aufreinigung: Purified

Reinheit: Protein A affinity chromatography

Immunogen: Human thyroid follicular cells were used as the immunogen for the recombinant TG antibody.

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting points. Titration of the recombinant TG antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.1-0.2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the recombinant TG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu Thyroglobulin

Target: Thyroglobulin (TG)

Andere Bezeichnung: TG / Thyroglobulin

Hintergrund: Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland. Human TG (HTG) is a homodimer of subunits each containing 2768 amino acids as synthesized (a short signal peptide may be removed from the N-terminus in the mature protein).

The protein is a precursor of the thyroid hormones, these are produced when thyroglobulin's tyrosine residues are combined with iodine and the protein is subsequently cleaved. Each thyroglobulin molecule contains approximately 100-120 tyrosine residues, but only a small number (20) of these are subject to iodination by thyroperoxidase in the follicular colloid. Therefore, each Tg molecule forms only approximately 10 thyroid hormone molecules. [Wiki]

Pathways: Thyroid Hormone Synthesis