O3FAR1 Antikörper (N-Term)

Produktnummer ABIN5706869

Produktdetails anti-O3FAR1 Antikörper

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Bindungsspezifität: N-Term

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser O3FAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale:

Synonyms: rabbit anti-Ffar4 antibody, Ffar-4, Ffar 4, free fatty acid receptor 4, omega-3 fatty acid receptor 1, G-protein coupled receptor 120, G-protein coupled receptor GT01,  Gpr120, O3far1

Background: Anti-Ffar4 Antibody was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). Free Fatty Acid 4 receptor (Ffa4 receptor or GPR120), a rhodopsin-like G protein coupled receptor (GPCR) subfamily member, is a receptor that senses specific fatty acids such as omega-3 fatty acid in fish oil or the endogenous signaling lipid, PHASA. Ffa4 receptor is enriched in lung, colon and adipose tissue but is also detected in many other tissues and cells. The activation of Ffar4 has multiple effects, including but not limited to inhibition of inflammation, improving insulin sensitivity and adipogenesis, and regulating hormone secretion from the gastro-intestinal system and pancreatic islets. Therefore, approaches that regulate FFA4 receptor activity could be developed as promising anti-diabetic and anti-inflammation drugs. GPR120 is the only fatty acid receptor that can sense lipids in adipose tissue, mature adipocytes, CD11c+ macrophages, and RAW264.7 cells making this receptor of potential importance in the prevention and treatment of metabolic and inflammatory diseases.

Gene Name: Ffar4

Aufreinigung: Anti-Ffar4 is directed against mouse Ffar4 at a n-terminal position. This product is an affinity purified antibody produced by immunoaffinity chromatography using peptide coupled to agarose beads.  A BLAST analysis was used to suggest reactivity with this protein in rat based on 100% homology match for the immunogen sequence.

Immunogen:

Immunogen: Affinity purified Anti-Ffar4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide near the N-terminus portion of mouse Ffar4 protein.

Immunogen Type: Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Application Note: Anti-Ffar4 Antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band ~40-48 kDa in size corresponding to Ffar4 by western blotting in the appropriate cell lysate or extract. Tested using positive controls Raw 264.7 WCL p/n W10-001-369 and NIH/3T3 WCL p/n W10-000-358.

Western Blot Dilution: 1.0 μg/mL

ELISA Dilution: 1:50,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride,  pH 7.2

Stabilizer: None

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 12 months

Details zu O3FAR1

Target: O3FAR1 (omega-3 Fatty Acid Receptor 1 (O3FAR1))

Andere Bezeichnung: Ffar4 (O3FAR1 Produkte)

Synonyme: BMIQ10 antikoerper, GPR120 antikoerper, GPR129 antikoerper, GT01 antikoerper, O3FAR1 antikoerper, PGR4 antikoerper, AI552415 antikoerper, Gpr120 antikoerper, Gpr129 antikoerper, KPG_013 antikoerper, O3far1 antikoerper, Pgr4 antikoerper, free fatty acid receptor 4 antikoerper, phosphodiesterase 6C antikoerper, FFAR4 antikoerper, Ffar4 antikoerper, PDE6C antikoerper

Gen-ID: 107221

NCBI Accession: NP_861413

UniProt: Q7TMA4

Pathways: Hormone Transport