INSIG1 Antikörper

Produktnummer ABIN5703038

Der Kaninchen Polyklonal Anti-INSIG1-Antikörper wurde für WB, ELISA, IHC, IF und IP validiert. Er ist geeignet, INSIG1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für INSIG1 Antikörper (ABIN5703038)

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INSIG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-INSIG1 Antikörper

Immunogen: insulin induced gene 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

A549 cells were subjected to SDS PAGE followed by western blot with FNab04333(INSIG1 antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Andere Bezeichnung: INSIG1

Hintergrund: Synonyms:CL 6, INSIG 1, INSIG1, insulin induced gene 1, Insulin induced gene 1 protein Background:Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins(SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation(ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

Molekulargewicht: 28-31, 66-70 kDa

Gen-ID: 3638

UniProt: O15503

Pathways: ER-Nucleus Signaling