ADAR Antikörper

Produktnummer ABIN5699808

Dieses Anti-ADAR-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ADAR in WB, IHC, ELISA, IF und IP. Geeignet für Human, Maus, Ratte und Schwein.

Kurzübersicht für ADAR Antikörper (ABIN5699808)

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Produktdetails anti-ADAR Antikörper

Immunogen: adenosine deaminase, RNA-specific

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB :1:500-1:5000,IHC:1:20-1:200,IP:1:200-1:2000,IF:1:20-1:200

Kommentare:

HeLa cells were subjected to SDS PAGE followed by western blot with FNab00150( ADAR1 Antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu ADAR

Target: ADAR (Adenosine Deaminase, RNA-Specific (ADAR))

Andere Bezeichnung: ADAR1

Hintergrund: Synonyms:ADAR, ADAR1, adenosine deaminase, RNA, DRADA, DSH, DSRAD, G1P1, IFI 4, IFI4, Interferon inducible protein 4, K88dsRBP, p136 Background:ADAR1 is also named as ADAR1, DSRAD, G1P1, IFI4. It convert selected adenosine residues into inosine in substrate RNAs containing a relatively short dsRNA region(PMID:15556947). The human ADAR1 gene specifies two size forms of RNA-specific adenosine deaminase, an interferon(IFN) inducible ?150 kDa protein and a constitutively expressed N-terminally truncated ?110 kDa protein, encoded by transcripts with alternative exon 1 structures that initiate from different promoters(PMID:11111054). It has 5 isoforms produced by alternative promoter usage and alternative splicing. Defects in ADAR are a cause of dyschromatosis symmetrical hereditaria(DSH).ADAR1 can form respective homodimers, and this association is essential for its enzymatic activities(PMID:17428802).

Molekulargewicht: 136kDa,observed 110kDa

UniProt: P55265

Pathways: Protein targeting to Nucleus