ABAT Antikörper

Produktnummer ABIN5699780

Der Kaninchen Polyklonal Anti-ABAT-Antikörper wurde für WB, IHC, ELISA und IP validiert. Er ist geeignet, ABAT in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ABAT Antikörper (ABIN5699780)

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABAT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Produktdetails anti-ABAT Antikörper

Immunogen: 4-aminobutyrate aminotransferase

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:200-1:2000,IHC:1:20-1:200,IP:1:200-1:2000

Kommentare:

human liver tissue were subjected to SDS PAGE followed by western blot with FNab00026(ABAT antibody) at dilution of 1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu ABAT

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Andere Bezeichnung: ABAT

Hintergrund: Synonyms:ABAT, FLJ17813, GABA aminotransferase, GABA AT, GABA T, GABA transaminase, GABAT, L AIBAT Background:4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Molekulargewicht: 55kDa

Gen-ID: 18

UniProt: P80404

Pathways: Monocarboxylic Acid Catabolic Process