ABAT Antikörper (C-Term)

Produktnummer ABIN2854328

Produktdetails anti-ABAT Antikörper

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABAT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Rabbit Polyclonal antibody to ABAT (4-aminobutyrate aminotransferase)
ABAT antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ABAT. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Kommentare:

Positive Control: Mouse brain , Rat liver

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.49 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu ABAT

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Andere Bezeichnung: 4-aminobutyrate aminotransferase (ABAT Produkte)

Synonyme: cb880 antikoerper, fj82a01 antikoerper, wu:fj82a01 antikoerper, BA0325 antikoerper, PSPTO0259 antikoerper, PSPTO0301 antikoerper, PSPTO1890 antikoerper, GABA-AT antikoerper, GABAT antikoerper, NPD009 antikoerper, GABA-T antikoerper, L-AIBAT antikoerper, 9630038C02Rik antikoerper, AI255750 antikoerper, ENSMUSG00000051226 antikoerper, Gabaat antikoerper, Gabat antikoerper, Gm9851 antikoerper, I54 antikoerper, Laibat antikoerper, X61497 antikoerper, beta-AlaAT antikoerper, 4-aminobutyrate aminotransferase antikoerper, 4-aminobutyrate--2-oxoglutarate transaminase antikoerper, GABA aminotransferase PLP-dependent PuuE antikoerper, 4-aminobutyrate aminotransferase, mitochondrial antikoerper, aspartate aminotransferase family protein antikoerper, 4-aminobutyrate aminotransferase S homeolog antikoerper, ABAT antikoerper, abat antikoerper, gabT antikoerper, puuE antikoerper, gabT-1 antikoerper, gabT-2 antikoerper, gabT-3 antikoerper, CNE01830 antikoerper, Mmwyl1_0047 antikoerper, CpipJ_CPIJ008729 antikoerper, KCR_RS04555 antikoerper, Bcenmc03_4909 antikoerper, Hden_0972 antikoerper, Dbac_2000 antikoerper, Mesil_2400 antikoerper, Trad_0121 antikoerper, abat.S antikoerper, Abat antikoerper

Hintergrund: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Cellular Localization: Mitochondrion matrix

Molekulargewicht: 56 kDa

Gen-ID: 18

UniProt: P80404

Pathways: Monocarboxylic Acid Catabolic Process