MMP2 Antikörper

Produktnummer ABIN5699311

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MMP2 in WB, IHC, ELISA und IP. Er zeigt eine Reaktivität gegenüber Human, Ratte, Maus und Zebrafisch (Danio rerio).

Kurzübersicht für MMP2 Antikörper (ABIN5699311)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Produktdetails anti-MMP2 Antikörper

Immunogen: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:200-1:2000 IP : 1:200-1:1000 IHC : 1:100-1:400 IF : 1:50-1:500

Kommentare:

MCF7 cells were subjected to SDS PAGE followed by western blot with FNab05238(MMP2 antibody) at dilution of 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Andere Bezeichnung: MMP2

Hintergrund: Synonyms:72 kDa gelatinase, 72 kDa type IV collagenase, CLG4, CLG4A, Gelatinase A, Matrix metalloproteinase 2, MMP 2, MMP II, MMP2, MONA, TBE 1 Background:This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 72 kDa, 60 kDa

Gen-ID: 4313

UniProt: P08253

Pathways: Activation of Innate immune Response