PROX1 Antikörper (C-Term)

Produktnummer ABIN569679

Dieser Anti-PROX1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von PROX1 in WB, IHC (p) und IHC (fro). Geeignet für Human, Maus, Ratte und Fisch.

Kurzübersicht für PROX1 Antikörper (C-Term) (ABIN569679)

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Reaktivität: Human, Maus, Ratte, Fisch

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PROX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PROX1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody is reactive with Prox-1. It will be a useful tool to study lymphatic vessel density in and around human tumors. It will detect Prox-1 in the nucleus of lymphatic endothelial cells.

Aufreinigung: Purified

Immunogen: Peptide corresponding to the Homeobox domain of Prox1.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store lyophilized (preferably in a desiccator) at -20 °C and in aliquots at -80 °C. Reconstituted antibody can be stored at 4 °C for a limited period of time, it does not show decline in activity after two weeks at 4 °C.

Details zu PROX1

Target: PROX1 (Prospero Homeobox 1 (PROX1))

Andere Bezeichnung: PROX-1

Hintergrund: The homeobox gene Prox-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. Prox-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. Prox-1-deficient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. Human Prox-1 gene has been mapped to chromosome 1q32.2-q32.3, and its product shows 94 % similarity to the chicken protein. The conserved structure and expression pattern of the Prox-1 gene imply that it may play the same roles in humans as in other vertebrates. The human Prox-1 gene is most actively expressed in the developing lens. Anti-Prox-1 antibodies provide a highly specific marker of lymphatic endothelial cells.Synonyms: Homeobox prospero-like protein PROX1, PROX1, Prospero homeobox protein 1

Gen-ID: 5629

NCBI Accession: NP_002754

UniProt: Q92786

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation