FZD2 Antikörper (Internal Region)

Produktnummer ABIN569657

Der Ziege Polyklonal anti-FZD2 Antikörper wird verwendet zum Nachweis von FZD2 in Proben von Human, Ratte und Maus. Er wurde validiert für IHC (p) und EIA.

Kurzübersicht für FZD2 Antikörper (Internal Region) (ABIN569657)

Target: FZD2 (Frizzled Family Receptor 2 (FZD2))

Reaktivität: Human, Ratte, Maus

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser FZD2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-FZD2 Antikörper

Bindungsspezifität: Internal Region

Sequenz: RYATLEHPFH CPR

Spezifität: Recognizes FZD2 / Frizzled-2.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_001457.1. Genename: FZD2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FZD2

Target: FZD2 (Frizzled Family Receptor 2 (FZD2))

Andere Bezeichnung: FZD2 / Frizzled-2

Hintergrund: FZD2 is a Frizzled Receptor that mediates Wnt signaling, which is required for proper axis development in the embryo. FZD2 is developmentally regulated. Studies of rat FZD2 indicate that the protein signals through a calcium-releasing pathway and that FDZ2 expression modulates protein kinase C (PKC) localization and stimulates PKC activity in vitro. Increased levels of FZD2 mRNA have been observed in primary gastric cancer and in head and neck squamous carcinoma and gastric cancer cell lines. FZD2 expression has been documented in human brain, heart, kidney, lung, colon, ovary and stomach. High levels of expression have been observed in fetal kidney and lung and adult colon and ovary. ESTs have been isolated from human tissue libraries, including cancerous kidney, lung, lymph and testis, and normal blood, cervix, embryo and kidney.Synonyms: Fz-2, FzE2, hFz2

Gen-ID: 2535

NCBI Accession: NP_001457

UniProt: Q14332

Pathways: WNT Signalweg