Isocitrate Dehydrogenase Antikörper (Internal Region)

Produktnummer ABIN569649

Der Ziege Polyklonal anti-Isocitrate Dehydrogenase Antikörper (ABIN569649) detektiert spezifisch Isocitrate Dehydrogenase in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Hund, Schaf und Rind (Kuh).

Kurzübersicht für Isocitrate Dehydrogenase Antikörper (Internal Region) (ABIN569649)

Target: Isocitrate Dehydrogenase (IDH)

Reaktivität: Human, Ratte, Maus, Hund, Schaf, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Isocitrate Dehydrogenase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Isocitrate Dehydrogenase Antikörper

Bindungsspezifität: AA 65-77, Internal Region

Sequenz: KKHNVGVKCA TIT

Spezifität: Recognizes IDH1 (65-77).

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog), Sheep.
Species reactivity (tested):Human, Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_005887.2.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Isocitrate Dehydrogenase

Target: Isocitrate Dehydrogenase (IDH)

Andere Bezeichnung: Isocitrate Dehydrogenase / IDH

Hintergrund: IDH1 belongs to two distinct subclasses. The protein is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. This protein contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.Synonyms: Cytosolic NADP-isocitrate dehydrogenase, ICDH, IDP, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD, cytoplasmic Isocitrate dehydrogenase [NADP]

Molekulargewicht: 46.7kDa (NP_005887.2).

Gen-ID: 3417

NCBI Accession: NP_005887

UniProt: O75874