PCBP1 Antikörper (Internal Region)

Produktnummer ABIN569643

Der Ziege Polyklonal anti-PCBP1 Antikörper (ABIN569643) detektiert spezifisch PCBP1 in WB und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte und Hund.

Kurzübersicht für PCBP1 Antikörper (Internal Region) (ABIN569643)

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser PCBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-PCBP1 Antikörper

Bindungsspezifität: AA 234-247, Internal Region

Sequenz: C-ADLAKLNQVA RQQSH

Spezifität: Recognizes PCBP1 (234-247).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine (Dog).
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_006187.2. Genename: PCBP1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PCBP1

Target: PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))

Andere Bezeichnung: PCBP1

Hintergrund: The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.Synonyms: Alpha-CP1, HNRPE1, HNRPX, Heterogeneous nuclear ribonucleoprotein E1, Nucleic acid-binding protein SUB2.3, Poly(rC)-binding protein 1, SUB2.3, hnRNP E1

Gen-ID: 5093

NCBI Accession: NP_006187

UniProt: Q15365