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USP7 Antikörper (AA 258-483)

USP7 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5693267
  • Target Alle USP7 Antikörper anzeigen
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Bindungsspezifität
    • 14
    • 11
    • 8
    • 8
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 258-483
    Reaktivität
    • 86
    • 35
    • 29
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 75
    • 9
    • 2
    Kaninchen
    Klonalität
    • 66
    • 20
    Polyklonal
    Konjugat
    • 44
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser USP7 Antikörper ist unkonjugiert
    Applikation
    • 66
    • 27
    • 26
    • 15
    • 13
    • 12
    • 11
    • 10
    • 9
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-HAUSP/USP7 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-HAUSP/USP7 Antibody Picoband® (ABIN5693267). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Immunogen
    E. coli-derived human HAUSP/USP7 recombinant protein (Position: L258-D483).
    Isotyp
    IgG
    Top Product
    Discover our top product USP7 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Immunocytochemistry/Immunofluorescence, 2 μg/mL
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells
    ELISA, 0.1-0.5 μg/mL
    1. "Entrez Gene: USP7 ubiquitin specific peptidase 7 (herpes virus-associated)". 2. Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L (Nov 2003). "Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP". The Journal of Biological Chemistry. 278 (48): 47753-61. 3. Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W (Apr 2002). "Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization". Nature. 416 (6881): 648-53.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))
    Andere Bezeichnung
    USP7 (USP7 Produkte)
    Hintergrund

    Synonyms: Ubiquitin carboxyl-terminal hydrolase 7

    Tissue Specificity: Widely expressed. Overexpressed in prostate cancer.

    Background: Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is an enzyme that in humans is encoded by the USP7 gene. The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder.

    Molekulargewicht
    140 kDa
    Gen-ID
    7874
    UniProt
    Q93009
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