GSTM1 Antikörper

Produktnummer ABIN5693233

Der Maus Monoklonal Anti-GSTM1-Antikörper wurde für WB, IHC, ICC und FACS validiert. Er ist geeignet, GSTM1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für GSTM1 Antikörper (ABIN5693233)

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GSTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Klon: 11F2

Produktdetails anti-GSTM1 Antikörper

Verwendungszweck: Anti-GSTM1 Antibody Picoband® (monoclonal, 11F2)

Sequenz: EEEKIRVDIL ,ENQTMDNHMQ LGMICYNPEF EKLK

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-GSTM1 Antibody Picoband® (monoclonal, 11F2) (ABIN5693233). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human GSTM1, which shares 70.6% and 73.5% amino acid (aa) sequence identity with mouse and rat GSTM1, respectively.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunocytochemistry, 0.5-1 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
1. Carless, M. A., Lea, R. A., Curran, J. E., Appleyard, B., Gaffney, P., Green, A., Griffiths, L. R. TheGSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population. J. Invest. Derm. 119: 1373-1378, 2002. 2. Zhong, S., Wyllie, A. H., Barnes, D., Wolf, C. R., Spurr, N. K. Relationship between theGSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer.Carcinogenesis 14: 1821-1824, 1993.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu GSTM1

Target: GSTM1 (Glutathione S-Transferase mu 1 (GSTM1))

Andere Bezeichnung: GSTM1

Hintergrund:

Synonyms: Glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GSTM1, GST1

Tissue Specificity: Liver (at protein level).

Background: Glutathione S-transferase Mu 1 (gene name GSTM1) is a human glutathione S-transferase. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

Molekulargewicht: 26 kDa

Gen-ID: 2944

UniProt: P09488

Pathways: Negative Regulation of Transporter Activity