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MYBPC3 Antikörper (AA 1070-1123)

Der Kaninchen Polyklonal Anti-MYBPC3-Antikörper wurde für ELISA, WB und IHC validiert. Er ist geeignet, MYBPC3 in Proben von Human, Ratte und Maus zu detektieren. Es ist 1 Publikation verfügbar.
Produktnummer ABIN5693035

Kurzübersicht für MYBPC3 Antikörper (AA 1070-1123) (ABIN5693035)

Target

Alle MYBPC3 Antikörper anzeigen
MYBPC3 (Myosin Binding Protein C, Cardiac (MYBPC3))

Reaktivität

  • 39
  • 33
  • 25
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Ratte, Maus

Wirt

  • 50
  • 2
  • 2
Kaninchen

Klonalität

  • 52
  • 2
Polyklonal

Konjugat

  • 26
  • 6
  • 5
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MYBPC3 Antikörper ist unkonjugiert

Applikation

  • 44
  • 22
  • 21
  • 13
  • 6
  • 5
  • 4
  • 2
  • 2
  • 1
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 9
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1070-1123

    Verwendungszweck

    Anti-MYBPC3 Antibody Picoband®

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-MYBPC3 Antibody Picoband® (ABIN5693035). Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Immunogen

    E. coli-derived human MYBPC3 recombinant protein (Position: Q1070-H1123).

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    ELISA, 0.1-0.5 μg/mL
    1. Calore, C., De Bortoli, M., Romualdi, C., Lorenzon, A., Angelini, A., Basso, C., Thiene, G., Iliceto, S., Rampazzo, A., Melacini, P. A founder MYBPC3 mutation results in HCM with a high risk of sudden death after the fourth decade of life. J. Med. Genet. 52: 338-347, 2015. 2. Ehlermann, P., Weichenhan, D., Zehelein, J., Steen, H., Pribe, R., Zeller, R., Lehrke, S., Zugck, C., Ivandic, B. T., Katus, H. A. Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene. BMC Med. Genet. 9: 95, 2008.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Qian, Gong, Yang, Chen, Chen, Xu, Wu, Tang, Gao, Zeng: "Diastolic dysfunction in spontaneous type 2 diabetes rhesus monkeys: a study using echocardiography and magnetic resonance imaging." in: BMC cardiovascular disorders, Vol. 15, pp. 59, (2015) (PubMed).

  • Target

    MYBPC3 (Myosin Binding Protein C, Cardiac (MYBPC3))

    Andere Bezeichnung

    MYBPC3

    Hintergrund

    Synonyms: Myosin-binding protein C, cardiac-type, Cardiac MyBP-C, C-protein, cardiac muscle isoform, MYBPC3

    Tissue Specificity: Red blood cells.

    Background: The myosin-binding protein C, cardiac-type is a protein that in humans is encode by the MYBPC3 gene. MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.

    Molekulargewicht

    160 kDa

    Gen-ID

    4607

    UniProt

    Q14896
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