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STUB1 Antikörper (AA 51-303)

STUB1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, FACS, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5693017
  • Target Alle STUB1 Antikörper anzeigen
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    Bindungsspezifität
    • 14
    • 8
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-303
    Reaktivität
    • 69
    • 42
    • 38
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 63
    • 5
    • 1
    Kaninchen
    Klonalität
    • 55
    • 14
    Polyklonal
    Konjugat
    • 31
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser STUB1 Antikörper ist unkonjugiert
    Applikation
    • 48
    • 21
    • 13
    • 12
    • 12
    • 11
    • 9
    • 9
    • 7
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-STUB1 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Anti-STUB1 Antibody Picoband® (ABIN5693017). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Immunogen
    E. coli-derived human STUB1 recombinant protein (Position: R51-Y303).
    Isotyp
    IgG
    Top Product
    Discover our top product STUB1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
    Immunocytochemistry/Immunofluorescence, 2 μg/mL
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells
    ELISA, 0.1-0.5 μg/mL
    1. "Entrez Gene: STUB1 STIP1 homology and U-box containing protein 1". 2. Heimdal, K., Sanchez-Guixe, M., Aukrust, I., Bollerslev, J., Bruland, O., Jablonski, G. E., Erichsen, A. K., Gude, E., Koht, J. A., Erdal, S., Fiskerstrand, T., Haukanes, B. I., Boman, H., Bjorkhaug, L., Tallaksen, C. M. E., Knappskog, P. M., Johansson, S. STUB1 mutations in autosomal recessive ataxias--evidence for mutation-specific clinical heterogeneity. Orphanet J. Rare Dis. 9: 146, 2014.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
    Andere Bezeichnung
    STUB1 (STUB1 Produkte)
    Hintergrund

    Synonyms: E3 ubiquitin-protein ligase CHIP

    Tissue Specificity: Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.

    Background: STUB1 (STIP1 homology and U-Box containing protein 1), also known as CHIP (C terminus of HSC70-Interacting Protein), is a human gene. This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2.

    Molekulargewicht
    35 kDa
    Gen-ID
    10273
    Pathways
    Regulation of Hormone Metabolic Process, Response to Water Deprivation
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