CD31 Antikörper (AA 58-273)

Produktnummer ABIN5692990

Der Kaninchen Polyklonal Anti-CD31-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, CD31 in Proben von Maus zu detektieren. Es sind 16+ Publikationen verfügbar.

Kurzübersicht für CD31 Antikörper (AA 58-273) (ABIN5692990)

Target: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD31 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-CD31 Antikörper

Bindungsspezifität: AA 58-273

Verwendungszweck: Anti-CD31/Pecam1 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-CD31/Pecam1 Antibody Picoband® (ABIN5692990). Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: E. coli-derived mouse CD31 recombinant protein (Position: R58-Q273).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
Immunohistochemistry, 2-5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Donmez A, Tombuloglu M, Gulbahar O, Arik B, Cagirgan S, Vural F, Gokmen N."CD31 expression on peripheral blood stem cells predicts both early neutrophil and platelet engraftments."2013 Oct,49(2):307-12. 2. Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics 34 (2): 229-32. 3. Kellermair J, Redwan B, Alias S, Jabkowski J, Panzenboeck A, Kellermair L, Winter MP, Weltermann A, Lang IM."Platelet endothelial cell adhesion molecule 1 deficiency misguides venous thrombus resolution."2013 Nov 7, 122(19):3376-84. 4. Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science 247 (4947): 1219-22. 5. Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics 37 (2): 226-8.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Referenzen für anti-CD31 Antikörper (ABIN5692990)

Chen, Li, Peng, Jie, Dongye, Cai, Feng, Li, Zeng, Lun, Chen, Xu: "The induction of autophagy against mitochondria-mediated apoptosis in lung cancer cells by a ruthenium (II) imidazole complex." in: Oncotarget, Vol. 7, Issue 49, pp. 80716-80734, (2018) (PubMed).

Zhang, Peng, Yuan, Xie, Yang, Xue: "Peroxisome proliferator‑activated receptor γ mediates porcine placental angiogenesis through hypoxia inducible factor‑, vascular endothelial growth factor‑ and angiopoietin‑mediated signaling." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 2636-2644, (2018) (PubMed).

Fan, Qu, Chu, Gao, Gao, Chen, Tian: "MicroRNA-210 promotes angiogenesis in acute myocardial infarction." in: Molecular medicine reports, Vol. 17, Issue 4, pp. 5658-5665, (2018) (PubMed).

Atala: "Re: Treatment of Diabetes Mellitus-Induced Erectile Dysfunction Using Endothelial Progenitor Cells Genetically Modified with Human Telomerase Reverse Transcriptase." in: The Journal of urology, Vol. 197, Issue 2, pp. 494, (2017) (PubMed).

Chen, Yu, Gumireddy, Li, Yao, Gao, Chen, Hao, Wang, Huang, Xu, Ye: "ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer." in: Oncotarget, Vol. 6, Issue 9, pp. 6959-76, (2016) (PubMed).

Wang, Yang, Tang, Long, Huang: "Wound Dressing Model of Human Umbilical Cord Mesenchymal Stem Cells-Alginates Complex Promotes Skin Wound Healing by Paracrine Signaling." in: Stem cells international, Vol. 2016, pp. 3269267, (2016) (PubMed).

Zhang, Wang, Yang, Pan, Li, Yuan: "Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing." in: Oncology letters, Vol. 11, Issue 5, pp. 3265-3272, (2016) (PubMed).

Zeng, Zhao, Ouyang, Zhao, Zhang, Chen, Yu, Lei: "Label-retaining assay enriches tumor-initiating cells in glioblastoma spheres cultivated in serum-free medium." in: Oncology letters, Vol. 12, Issue 2, pp. 815-824, (2016) (PubMed).

Li, Zeng, Qi, Tang, Zhang, Wu, Liang, Shi, Liu, Zhang: "Xenotransplantation of human adipose-derived stem cells in zebrafish embryos." in: PLoS ONE, Vol. 10, Issue 4, pp. e0123264, (2015) (PubMed).

Xiu, Fan, Li, Cui, Lei: "Different angiogenic abilities of self-setting calcium phosphate cement scaffolds consisting of different proportions of fibrin glue." in: BioMed research international, Vol. 2014, pp. 785146, (2014) (PubMed).

Wu, Chang, Zhang, Zhang, Tian, Feng, Zhou, Zheng, Han, Huang: "SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions." in: Journal of Cancer, Vol. 4, Issue 9, pp. 727-35, (2013) (PubMed).

Zhou, Yi, Liu, Bian, Qi, He, Wang, Li, Zhao, Huang, Wei: "Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis." in: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M112.017988, (2012) (PubMed).

Chen, Jia, Ma, Wang, Teng: "In vivo serial MR imaging of magnetically labeled endothelial progenitor cells homing to the endothelium injured artery in mice." in: PLoS ONE, Vol. 6, Issue 6, pp. e20790, (2011) (PubMed).

Chen, Chan, Yuan, Hu, Huang, Ma, Wang, Dong, Tang, Xie, Li, Guan: "CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients." in: The Journal of clinical investigation, Vol. 120, Issue 4, pp. 1178-91, (2010) (PubMed).

Qiu, Yang, Pei, Zhang, Ding: "WSS25 inhibits growth of xenografted hepatocellular cancer cells in nude mice by disrupting angiogenesis via blocking bone morphogenetic protein (BMP)/Smad/Id1 signaling." in: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32638-46, (2010) (PubMed).

Barone, Braun, Chase: "D-1/D-2 dopamine receptor interactions in the regulation of extrapyramidal motor function: studies in animal models and parkinsonian patients." in: Clinical neuropharmacology, Vol. 9 Suppl 4, pp. 128-30, (1987) (PubMed).

Details zu CD31

Target: CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Andere Bezeichnung: Pecam1

Hintergrund:

Synonyms: Platelet endothelial cell adhesion molecule, PECAM-1, CD31, Pecam1, Pecam, Pecam-1

Tissue Specificity: Isoform 1 and isoform 3 are expressed in lung and platelets.

Background: CD31 also known as Platelet endothelial cell adhesion molecule (PECAM-1), is a protein that in human is encoded by the PECAM1 gene. Encoded protein is a member of the immunoglobulin superfamily and this gene is mapped to 17q23.3. CD31 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. It is demonstrated that CD31 expression on human PBSCs may positively affect both neutrophil and platelet engraftment. Meanwhile, CD31 is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution.

Molekulargewicht: 130 kDa

Gen-ID: 18613

UniProt: Q08481

Pathways: Regulation of Actin Filament Polymerization