IL17C Antikörper (AA 15-194)

Produktnummer ABIN5692881

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL17C in WB und ELISA. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für IL17C Antikörper (AA 15-194) (ABIN5692881)

Target: IL17C (Interleukin 17C (IL17C))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL17C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-IL17C Antikörper

Bindungsspezifität: AA 15-194

Verwendungszweck: Anti-IL17C Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-IL17C Antibody Picoband® (ABIN5692881). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Immunogen: E. coli-derived mouse IL17C recombinant protein (Position: H15-Q194).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL
ELISA (Cap), 1-5 μg/mL
1. Chang, S. H., Reynolds, J. M., Pappu, B. P., Chen, G., Martinez, G. J., Dong, C. Interleukin-17C promotes Th17 cell responses and autoimmune disease via interleukin-17 receptor E.Immunity 35: 611-621, 2011. 2. Conti, H. R., Whibley, N., Coleman, B. M., Garg, A. V., Jaycox, J. R., Gaffen, S. L. Signaling through IL-17C/IL-17RE is dispensable for immunity to systemic, oral and cutaneous candidiasis. PLoS One 10: e0122807, 2015.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu IL17C

Target: IL17C (Interleukin 17C (IL17C))

Andere Bezeichnung: Il17c

Hintergrund:

Synonyms: Interleukin-17C, Il-17c, Cytokine CX2, Il17c

Tissue Specificity: Expressed by epithelial cells after bacterial challenge. Low expression, if any, in lymphocytes.

Background: IL17C, also known as CX2, is a protein that in humans is encoded by the IL17C gene. IL17C is mapped to 16q24.3. The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. IL17C is an essential autocrine cytokine regulating innate epithelial immune responses. It also plays an important role in the pathogenesis of inflammatory arthritis.

Molekulargewicht: 20 kDa

Gen-ID: 234836

UniProt: Q8K4C5

Pathways: Cellular Response to Molecule of Bacterial Origin