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IL17C Antikörper (AA 101-197)

IL17C Reaktivität: Human, Maus, Ratte WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN747983
  • Target Alle IL17C Antikörper anzeigen
    IL17C (Interleukin 17C (IL17C))
    Bindungsspezifität
    • 14
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-197
    Reaktivität
    • 32
    • 20
    • 16
    • 3
    Human, Maus, Ratte
    Wirt
    • 28
    • 5
    • 2
    • 1
    Kaninchen
    Klonalität
    • 31
    • 5
    Polyklonal
    Konjugat
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL17C Antikörper ist unkonjugiert
    Applikation
    • 32
    • 13
    • 12
    • 12
    • 9
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human IL-17C
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Huang, Meng, Hong, Lin, Jin, Dong: "IL-17C is required for lethal inflammation during systemic fungal infection." in: Cellular & molecular immunology, Vol. 13, Issue 4, pp. 474-83, (2017) (PubMed).

    Huang, Yuan, Zhu, Yin, Hong, Dong, Jin, Dong: "IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 198, Issue 2, pp. 669-680, (2016) (PubMed).

  • Target
    IL17C (Interleukin 17C (IL17C))
    Andere Bezeichnung
    IL-17C (IL17C Produkte)
    Synonyme
    IL17C antikoerper, il17-3 antikoerper, CX2 antikoerper, IL-17C antikoerper, IL-21 antikoerper, interleukin 17C antikoerper, interleukin 17c antikoerper, IL17C antikoerper, il17c antikoerper, Il17c antikoerper
    Hintergrund

    Synonyms: CX2, IL-17C, Interleukin-17C, Cytokine CX2, IL17C, UNQ561/PRO1122

    Background: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

    Gen-ID
    27189
    UniProt
    Q9P0M4
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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