VCAM1 Antikörper (Vascular Cell Adhesion Molecule 1) (AA 25-270)

Details for Product anti-VCAM1 Antibody No. ABIN5692810, Anbieter: Anmelden zum Anzeigen
Antigen
  • CD106
  • INCAM-100
  • Vcam-1
  • VCAM1B
  • fi76d06
  • wu:fi76d06
  • zgc:158875
  • VCAM1
  • vascular cell adhesion molecule 1
  • vascular cell adhesion molecule 1b
  • VCAM1
  • Vcam1
  • vcam1b
  • VCAM-1
Epitop
AA 25-270
25
15
14
11
10
8
8
6
5
5
5
5
5
5
4
4
3
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Human
450
209
85
33
11
9
8
3
1
Wirt
Kaninchen
351
158
126
16
14
8
Klonalität
Polyklonal
Konjugat
Dieser VCAM1 Antikörper ist unkonjugiert
68
59
55
20
12
9
9
6
6
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
388
240
211
157
143
107
63
46
43
26
26
24
17
13
10
5
4
3
3
3
2
2
2
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Marke Picoband™
Immunogen E. coli-derived human VCAM1 recombinant protein (Position: F25-L270).
Kreuzreaktivität (Details) No cross reactivity with other proteins.
Produktmerkmale Rabbit IgG polyclonal antibody for VCAM1 detection. Tested with WB, ELISA(Cap) in Human.
Plasmids, Primers & others Plasmide, Primers & weitere VCAM1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung VCAM1 (VCAM1 Antibody Abstract)
Hintergrund

Synonyms: Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, CD106, VCAM1

Tissue Specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Background: CD106(cluster of differentiation 106) also known as vascular cell adhesion molecule 1(VCAM-1), is a protein that in humans is encoded by the VCAM1 gene. In inflammatory conditions and in cardiac allografts undergoing rejection, VCAM1 is upregulated in endothelium of postcapillary venules. Arterial expression of VCAM1 is also found in experimental models of atherosclerosis in the rabbit. This gene is mapped to chromosome 1 by Southern analysis of somatic cell hybrids. VCAM-1 functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, andbasophils to vascularendothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development ofatherosclerosis and rheumatoid arthritis. CAM741 works similar to cotransin in that it represses the biosynthesis of VCAM1 cells by blocking the process of cotranslational translocation, which is dependent on the signal peptide ofVCAM1. Among the lung metastasis signature genes identified, several, includingVCAM1, were functionally validated.

UniProt P19320
Pathways Carbohydrate Homeostasis
Applikations-hinweise

Application Details: Western blot, 0.1-0.5&mu,g/mL
ELISA(Cap), 1-5&mu,g/mL

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Buffer Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Bilder des Herstellers
Western Blotting (WB) image for anti-Vascular Cell Adhesion Molecule 1 (VCAM1) (AA 25-270) antibody (ABIN5692810) Western blot analysis of VCAM1 using anti-VCAM1 antibody . Electrophoresis was perfo...
Produkt verwendet in: Ma, Pan, Ren, Guo, Guo, Wei, Zheng, Chen: "15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell." in: Lipids in health and disease, Vol. 16, Issue 1, pp. 137, 2018 (PubMed).

Wang, Qing, Liu, Liu, Qiao, Cui, He, Zhao, Liu, Yan, Wang, Liang, Guo, Shen, Hou, Chen: "Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling." in: Stem cell research & therapy, Vol. 8, Issue 1, pp. 188, 2018 (PubMed).

Hoffman, Adeli: "LDL Receptor Gene-Ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia with Dominant Inheritance and Diet-Induced Coronary Atherosclerosis." in: EBioMedicine, Vol. 28, pp. 17-18, 2018 (PubMed).

Tian, Tao, Zhao, Tai, Liu, Liu: "Isolation and morphological characterization of ovine amniotic fluid mesenchymal stem cells." in: Experimental animals, Vol. 65, Issue 2, pp. 125-34, 2017 (PubMed).

Ma, Pan, Chen, Guo, Zhao, Zheng, Chen: "Trimethylamine N-oxide in atherogenesis: impairing endothelial self-repair capacity and enhancing monocyte adhesion." in: Bioscience reports, Vol. 37, Issue 2, 2017 (PubMed).

Chen, Zhang, Chen, Liu, Wang, Zhou, Qiu, Zhang, Teng, Mao, Liu, Wei, Li: "Retinoic Acid promotes interleukin-4 plasmid-dimethylsulfoxide topical transdermal delivery for treatment of psoriasis." in: Annals of dermatology, Vol. 27, Issue 2, pp. 121-7, 2015 (PubMed).

Yu, Ge, Summers, Li, Liu, Ma, Kaminski, Zhuang: "TSP-1 secreted by bone marrow stromal cells contributes to retinal ganglion cell neurite outgrowth and survival." in: PLoS ONE, Vol. 3, Issue 6, pp. e2470, 2008 (PubMed).

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