Lamin A/C Antikörper (AA 319-566) (FITC)

Produktnummer ABIN5691105

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Lamin A/C in ICC, FACS und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Hund, Hamster und Schaf.

Kurzübersicht für Lamin A/C Antikörper (AA 319-566) (FITC) (ABIN5691105)

Target: Lamin A/C (LMNA)

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Hamster, Schaf

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Lamin A/C Antikörper ist konjugiert mit FITC

Applikation: Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 131C3

Produktdetails anti-Lamin A/C Antikörper (FITC)

Bindungsspezifität: AA 319-566

Spezifität: 131C3 reacts with an epitope located between residues 319-566 in lamin A and C.

Immunogen: 131C3 is a mouse monoclonal IgG1/k antibody derived by fusion of P3/X63.Ag8.653 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with purified rat liver lamins.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: 131C3 is suitable for immunocytochemistry, immunohistochemistry on frozen sections and flow cytometry. Optimal antibody dilutions for the different applications should be determined by titration. The recommended dilution is 1:10.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Each vial contains 1 mL FITC-conjugated anti lamin A and C monoclonal antibody in PBS containing 0.1 % BSA, 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C, or in small aliquots at -20°C.

Details zu Lamin A/C

Target: Lamin A/C (LMNA)

Andere Bezeichnung: Lamin A and C

Hintergrund: Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

Pathways: Apoptose, Caspase Kaskade in der Apoptose, ER-Nucleus Signaling, Protein targeting to Nucleus