LTB Antikörper (AA 31-221)

Produktnummer ABIN5690619

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch LTB in Func und FACS. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für LTB Antikörper (AA 31-221) (ABIN5690619)

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser LTB Antikörper ist unkonjugiert

Applikation: Functional Studies (Func), Flow Cytometry (FACS)

Klon: 4H8 WH2

Produktdetails anti-LTB Antikörper

Bindungsspezifität: AA 31-221

Spezifität: Recognizes mouse LTbetaR.

Reinheit: > 95% (SDS-PAGE)

Immunogen: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. In PBS containing 10 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least 1 year after receipt when stored at -20°C.

Details zu LTB

Target: LTB (Lymphotoxin beta (TNF Superfamily, Member 3) (LTB))

Andere Bezeichnung: LTbeta

Hintergrund: The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Gen-ID: 17000

UniProt: P50284

Pathways: NF-kappaB Signalweg