Vinculin Antikörper (AA 1060-1110)

Produktnummer ABIN5690319

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Vinculin in WB, ELISA, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Vinculin Antikörper (AA 1060-1110) (ABIN5690319)

Target: Vinculin (VCL)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Vinculin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Vinculin Antikörper

Bindungsspezifität: AA 1060-1110

Spezifität: Vinculin antibody is human, mouse and rat specific. At least three isoforms of Vinculin are known to exist.

Aufreinigung: Vinculin Antibody is affinity chromatography purified via peptide column.

Immunogen: Vinculin antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Vinculin.

The immunogen is located within amino acids 1060 - 1110 of Vinculin .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Vinculin antibody can be used for detection of Vinculin by Western blot at 1 - 2 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Vinculin Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Vinculin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu Vinculin

Target: Vinculin (VCL)

Andere Bezeichnung: Vinculin

Hintergrund: Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).

Molekulargewicht: Predicted: 117 kDa

Observed: 120kDa

Gen-ID: 7414

NCBI Accession: NP_003364

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2