Vinculin Antikörper (AA 1060-1110)

Produktnummer ABIN5690319

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Vinculin in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Vinculin Antikörper (AA 1060-1110) (ABIN5690319)

Target: Vinculin (VCL)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Vinculin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Vinculin Antikörper

Bindungsspezifität: AA 1060-1110

Spezifität: Vinculin antibody is human, mouse and rat specific. At least three isoforms of Vinculin are known to exist.

Aufreinigung: Vinculin Antibody is affinity chromatography purified via peptide column.

Immunogen: Vinculin antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Vinculin.

The immunogen is located within amino acids 1060 - 1110 of Vinculin .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Vinculin antibody can be used for detection of Vinculin by Western blot at 1 - 2 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Vinculin Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Vinculin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu Vinculin

Target: Vinculin (VCL)

Andere Bezeichnung: Vinculin

Hintergrund: Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).

Molekulargewicht: Predicted: 117 kDa

Observed: 120kDa

Gen-ID: 7414

NCBI Accession: NP_003364

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2