TRIP12 Antikörper (AA 1930-1980)

Produktnummer ABIN5690304

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TRIP12 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für TRIP12 Antikörper (AA 1930-1980) (ABIN5690304)

Target: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TRIP12 Antikörper

Bindungsspezifität: AA 1930-1980

Spezifität: TRIP12 antibody is human, mouse and rat reactive. At least four isoforms are known to exist.

Aufreinigung: TRIP12 antibody is affinity chromatography purified via peptide column.

Immunogen: TRIP12 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human TRIP12.

The immunogen is located within amino acids 1930 - 1980 of TRIP12.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TRIP12 antibody can be used for detection of TRIP12 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TRIP12 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: TRIP12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TRIP12

Target: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Andere Bezeichnung: TRIP12

Hintergrund: Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner (1). TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway and also modulates the NEDD8 pathway (2,3). TRIP12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site (4). TRIP12 acts as a key regulator of DNA damage response and the ubiquitin ligase activity of TRIP12 is essential for mouse development (5).

Molekulargewicht: Predicted: 219 kDa

Observed: 220 kDa

Gen-ID: 9320

NCBI Accession: NP_004229

UniProt: Q14669

Pathways: Nuclear Hormone Receptor Binding