TET1 Antikörper (AA 2030-2080)

Produktnummer ABIN5690283

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TET1 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für TET1 Antikörper (AA 2030-2080) (ABIN5690283)

Target: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TET1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-TET1 Antikörper

Bindungsspezifität: AA 2030-2080

Spezifität: TET1 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with TET2 and TET3.

Aufreinigung: TET1 antibody is affinity chromatography purified via peptide column.

Immunogen: TET1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET1.

The immunogen is located within amino acids 2030 - 2080 of TET1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TET1 antibody can be used for detection of TET1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TET1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: TET1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TET1

Target: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Andere Bezeichnung: TET1

Hintergrund: TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t(10,11)(q22,q23) (1). It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2). TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3). Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4).

Molekulargewicht: Predicted: 235 kDa

Observed: 240 kDa

Gen-ID: 80312

NCBI Accession: NP_085128

UniProt: Q8NFU7

Pathways: Stem Cell Maintenance, Warburg Effekt