KREMEN2 Antikörper (AA 390-440)

Produktnummer ABIN5690035

Produktdetails anti-KREMEN2 Antikörper

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Bindungsspezifität: AA 390-440

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KREMEN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Spezifität: Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.

Aufreinigung: KREMEN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 .

The immunogen is located within amino acids 390 - 440 of KREMEN2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: KREMEN2 Antibody can be used for detection of KREMEN2 by Western blot starting at 1 μ,g/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: KREMEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: KREMEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu KREMEN2

Target: KREMEN2 (Kringle Containing Transmembrane Protein 2 (KREMEN2))

Andere Bezeichnung: KREMEN2 (KREMEN2 Produkte)

Synonyme: krm2 antikoerper, KREMEN2 antikoerper, MGC147633 antikoerper, KRM2 antikoerper, 2900054E04Rik antikoerper, Krm2 antikoerper, kringle containing transmembrane protein 2 S homeolog antikoerper, kringle containing transmembrane protein 2 antikoerper, kremen2.S antikoerper, KREMEN2 antikoerper, kremen2 antikoerper, Kremen2 antikoerper

Hintergrund: KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

Molekulargewicht: Predicted: 51 kDa

Observed: 54 kDa

Gen-ID: 79412

NCBI Accession: NP_757384

UniProt: Q8NCW0

Pathways: WNT Signalweg