CD22 Antikörper (AA 839-843)

Produktnummer ABIN5689523

Dieses Anti-CD22-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CD22 in WB. Geeignet für Human.

Kurzübersicht für CD22 Antikörper (AA 839-843) (ABIN5689523)

Target: CD22 (CD22 Molecule (CD22))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-CD22 Antikörper

Bindungsspezifität: AA 839-843

Spezifität: This antibody detects endogenous level of total CD22 protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: CD22 antibody was raised against a peptide sequence around aa.839~843 (N-V-D-Y-V) derived from Human CD22.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu CD22

Target: CD22 (CD22 Molecule (CD22))

Andere Bezeichnung: CD22

Hintergrund: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Molekulargewicht: 140 kDa

Gen-ID: 933

NCBI Accession: NP_001762

UniProt: P20273