RUNX1 Antikörper (AA 6-10)

Produktnummer ABIN5689423

Der Kaninchen Polyklonal Anti-RUNX1-Antikörper wurde für WB validiert. Er ist geeignet, RUNX1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für RUNX1 Antikörper (AA 6-10) (ABIN5689423)

Target: RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RUNX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-RUNX1 Antikörper

Bindungsspezifität: AA 6-10

Spezifität: This antibody detects endogenous level of total AML1(RUNX1) protein.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: AML1 (RUNX1) antibody was raised against a peptide sequence around aa.6~10 (D-A-S-T-S) derived from Human AML1 (RUNX1).

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu RUNX1

Target: RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))

Andere Bezeichnung: AML1

Hintergrund: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.

Molekulargewicht: 55 kDa

Gen-ID: 861

NCBI Accession: NP_001116079

UniProt: Q01196