Choline Acetyltransferase Antikörper

Produktnummer ABIN5687549

Dieses Anti-Choline Acetyltransferase-Antikörper ist ein Ziege Polyklonal-Antikörper zur Detektion von Choline Acetyltransferase in WB und IHC. Geeignet für Human, Maus, Ratte, Huhn und Ziege. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Choline Acetyltransferase Antikörper (ABIN5687549)

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Reaktivität: Human, Maus, Ratte, Huhn, Ziege

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser Choline Acetyltransferase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Choline Acetyltransferase Antikörper

Spezifität: Specific for the ~ 70k choline acetyltransferase protein

Aufreinigung: Affinity Purified

Immunogen: Native choline acetyltransferase purified from human placenta.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Choline Acetyltransferase antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Referenzen für anti-Choline Acetyltransferase Antikörper (ABIN5687549)

Gonzales, Pare, Wichmann, Smith: "GABAergic inputs from direct and indirect striatal projection neurons onto cholinergic interneurons in the primate putamen." in: The Journal of comparative neurology, Vol. 521, Issue 11, pp. 2502-22, (2014) (PubMed).

Details zu Choline Acetyltransferase

Target: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Andere Bezeichnung: Choline Acetyltransferase

Hintergrund: Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).

Molekulargewicht: 70 kDa

Gen-ID: 1103

UniProt: P28329

Pathways: Skeletal Muscle Fiber Development