CIRBP Antikörper (C-Term)

Produktnummer ABIN568702

Dieser Ziege Polyklonal Antikörper detektiert spezifisch CIRBP in WB, IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Hund und Rind (Kuh).

Kurzübersicht für CIRBP Antikörper (C-Term) (ABIN568702)

Target: CIRBP (Cold Inducible RNA Binding Protein (CIRBP))

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CIRBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-CIRBP Antikörper

Bindungsspezifität: C-Term

Sequenz: C-RDSYDSYATH NE

Spezifität: Recognizes CIRBP (aa 161-172).

Kreuzreaktivität (Details): Species reactivity (expected):Rat, Canine (Dog), Bovine.
Species reactivity (tested):Human, Mouse.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C-Terminus of the protein sequence according to NP_001271.1. Genename: CIRBP

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CIRBP

Target: CIRBP (Cold Inducible RNA Binding Protein (CIRBP))

Andere Bezeichnung: CIRBP

Hintergrund: CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. It acts as a translational repressor. CIRBP is an immortalized gene in murine primary cells. CIRBP promotes assembly of stress granules (SGs), when overexpressed. It is a potential proto-oncogenic proteins upon overexpression. Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature.Synonyms: A18HNRNP, CIRP, Cold-inducible RNA-binding protein, Glycine-rich RNA-binding protein CIRP

Gen-ID: 1153

NCBI Accession: NP_001271

UniProt: Q14011

Pathways: Ribonucleoprotein Complex Subunit Organization