PMEPA1 Antikörper (AA 21-120)

Produktnummer ABIN5675664

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PMEPA1 in WB, ELISA, IHC (p), ICC, IF (cc), IF (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für PMEPA1 Antikörper (AA 21-120) (ABIN5675664)

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PMEPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PMEPA1 Antikörper

Bindungsspezifität: AA 21-120

Kreuzreaktivität: Human, Maus

Homologie: Rat,Sheep,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TMEPAI

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu PMEPA1

Target: PMEPA1 (Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1))

Andere Bezeichnung: TMEPAI

Hintergrund:

Synonyms: PMEPA_HUMAN, PMEPA1, Prostate transmembrane protein, androgen induced 1, Solid tumor associated 1 protein, Solid tumor-associated 1 protein, STAG1, TMEPAI, Transmembrane prostate androgen induced protein, Transmembrane prostate androgen-induced protein, Transmembrane, prostate androgen induced RNA.

Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).

Gen-ID: 56937

UniProt: Q969W9

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway