DNMT3B Antikörper (AA 251-350) (Biotin)

Produktnummer ABIN5675300

Dieses Anti-DNMT3B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DNMT3B in WB. Geeignet für Human und Maus.

Kurzübersicht für DNMT3B Antikörper (AA 251-350) (Biotin) (ABIN5675300)

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNMT3B Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB)

Produktdetails anti-DNMT3B Antikörper (Biotin)

Bindungsspezifität: AA 251-350

Kreuzreaktivität: Human, Maus

Homologie: Dog,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Dnmt3b

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu DNMT3B

Target: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Andere Bezeichnung: Dnmt3b

Hintergrund:

Synonyms: DNA (cytosine-5)-methyltransferase 3B, DNMT3B, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells (PubMed:27153398).

Gen-ID: 1789

UniProt: Q9UBC3