MMP2 Antikörper (AA 81-150) (HRP)
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- Target Alle MMP2 Antikörper anzeigen
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
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Bindungsspezifität
- AA 81-150
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Reaktivität
- Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MMP2 Antikörper ist konjugiert mit HRP
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Maus, Ratte
- Homologie
- Dog,Cow,Sheep,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human MMP2
- Isotyp
- IgG
- Top Product
- Discover our top product MMP2 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- MMP2 (Matrix Metalloproteinase 2 (MMP2))
- Andere Bezeichnung
- MMP2 (MMP2 Produkte)
- Synonyme
- 2-MMP antikoerper, CG1794 antikoerper, DM2-MMP antikoerper, Dm2-MMP antikoerper, Dmel\\CG1794 antikoerper, MMP2 antikoerper, anon-WO0118547.84 antikoerper, dm-2MMP antikoerper, dmmp2 antikoerper, l(2)02353 antikoerper, mmp2 antikoerper, wu:fa99h12 antikoerper, wu:fk89d01 antikoerper, fgmmp-2 antikoerper, Mmp-2 antikoerper, LOC100135793 antikoerper, Clg4a antikoerper, GelA antikoerper, MMP-2 antikoerper, CLG4 antikoerper, CLG4A antikoerper, MMP-II antikoerper, MONA antikoerper, TBE-1 antikoerper, matrix metallopeptidase 2 antikoerper, Matrix metalloproteinase 2 antikoerper, matrix metalloproteinase 2 antikoerper, matrix metalloproteinase-2 antikoerper, MMP2 antikoerper, Mmp2 antikoerper, mmp2 antikoerper, LOC657982 antikoerper, LOC100135793 antikoerper
- Hintergrund
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Synonyms: MMP2, MMP 2, 72 kDa gelatinase, 72kD type IV collagenase, CLG 4, CLG 4A, CLG4, CLG4A, Collagenase Type 4 alpha, Collagenase type IV A, Gelatinase A, Gelatinase alpha, Gelatinase neutrophil, Matrix metallopeptidase 2 gelatinase A 72 kDa gelatinase 72 kDa type IV collagenase, Matrix metalloproteinase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase), Matrix Metalloproteinase 2, Matrix metalloproteinase II, MMP 2, MMP II, MONA, Neutrophil gelatinase, TBE 1.,
Background: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
- Gen-ID
- 4313
- UniProt
- P08253
- Pathways
- Activation of Innate immune Response
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