FIP1L1 Antikörper (N-Term)

Produktnummer ABIN5673070

Der Kaninchen Polyklonal Anti-FIP1L1 Antikörper wurde für WB validiert. Er ist geeignet, FIP1L1 in Proben von Human zu detektieren.

Kurzübersicht für FIP1L1 Antikörper (N-Term) (ABIN5673070)

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FIP1L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-FIP1L1 Antikörper

Bindungsspezifität: N-Term

Sequenz: GIEDETAENG VPKPKVTETE DDSDSDSDDD EDDVHVTIGD IKTGAPQYGS

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of Human FIP1L1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FIP1L1

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Andere Bezeichnung: FIP1L1

Hintergrund: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alias Symbols: Rhe, FIP1, hFip1

Protein Size: 594

Gen-ID: 81608

NCBI Accession: NM_001134937, NP_001128409

UniProt: Q6UN15