Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

FIP1L1 Antikörper

FIP1L1 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7263123
  • Target Alle FIP1L1 Antikörper anzeigen
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Reaktivität
    • 25
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 23
    • 2
    Kaninchen
    Klonalität
    • 23
    • 2
    Polyklonal
    Konjugat
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FIP1L1 Antikörper ist unkonjugiert
    Applikation
    • 25
    • 13
    • 13
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human FIP1L1 (NP_001128409.1).
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    FIP1L1 (FIP1 Like 1 (FIP1L1))
    Andere Bezeichnung
    FIP1L1 (FIP1L1 Produkte)
    Synonyme
    FIP1 antikoerper, Rhe antikoerper, hFip1 antikoerper, 1300019H17Rik antikoerper, Rje antikoerper, fip1l1 antikoerper, wu:fd36f11 antikoerper, zgc:103421 antikoerper, factor interacting with PAPOLA and CPSF1 antikoerper, factor interacting with PAPOLA and CPSF1 S homeolog antikoerper, FIP1 like 1 (S. cerevisiae) antikoerper, FIP1 like 1b (S. cerevisiae) antikoerper, fip1l1 antikoerper, FIP1L1 antikoerper, fip1l1.S antikoerper, Fip1l1 antikoerper, fip1l1b antikoerper
    Hintergrund
    This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Molekulargewicht

    Observed_MW: 80 kDa

    Calculated_MW: 40 kDa/58 kDa/65 kDa/66 kDa

    Gen-ID
    81608
    UniProt
    Q6UN15
Sie sind hier:
Kundenservice