Nischarin Antikörper (C-Term)

Produktnummer ABIN5672022

Dieser Anti-Nischarin Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von Nischarin in WB. Geeignet für Human.

Kurzübersicht für Nischarin Antikörper (C-Term) (ABIN5672022)

Target: Nischarin (NISCH)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Nischarin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Nischarin Antikörper

Bindungsspezifität: C-Term

Sequenz: LLDEDCVHYP LPEFAKEPPQ RDRYRLDDGR RVRDLDRVLM GYQTYPQALT

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NISCH

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Nischarin

Target: Nischarin (NISCH)

Andere Bezeichnung: NISCH

Hintergrund: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis, possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor.

Alias Symbols: I-1, IR1, IRAS, hIRAS

Protein Size: 993

Gen-ID: 11188

NCBI Accession: NM_001276293, NP_001263222