Rekombinanter EPH Receptor A2 Antikörper (AA 183-510)
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- Target Alle EPH Receptor A2 (EPHA2) Antikörper anzeigen
- EPH Receptor A2 (EPHA2)
- Antikörpertyp
- Recombinant Antibody
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Bindungsspezifität
- AA 183-510
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Reaktivität
- Human
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Wirt
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Human
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Klonalität
- Monoklonal
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Konjugat
- Dieser EPH Receptor A2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Agonist (Agon), Internalization Assay (INA)
- Spezifität
- 1C1 binds specifically to the amino-termianal LBD (ligand-binding domain) region of the EphA2 ectodomain (IgG1 KD ~0.8 nM, Fab KD ~140 nM) and not to other related human Eph receptors such as EphA1, EphA2, and EphA4, or any EphB receptor family members.
- Produktmerkmale
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OriginalSpeciesName: Human
OriginalFormat: IgG1
- Aufreinigung
- Purified antibody.
- Immunogen
- 1C1 was isolated after screening of a non-immunized human Fab phage library. Selection was based on the ability to bind soluble human recombinant EphA2 (residues 183-510). The Fab was subsequently converted to full length human IgG1.
- Klon
- 1C1
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product EPHA2 Primärantikörper
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- Applikationshinweise
- This antibody binds to human Ephrin type-A receptor 2, a receptor tyrosine kinase that binds to membrane-bound ephrin-A ligands residing on adjacent cells, triggering contact-dependent signaling into neighboring cells. Eph2A is involved in pattern formation during development, angiogenesis and osteoblastogenesis. Eph2A has also been found to be expressed in a variety of cancers. This antibody acts as an agonist of Eph2A signaling. The agonist properties of 1C1 is due to ligand mimicry by VDR3. After cell binding, the antibody is able to induce rapid tyrosine phosphorylation, internalization, and degradation of the EphA2 receptor.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % Proclin 300.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- EPH Receptor A2 (EPHA2)
- Andere Bezeichnung
- Ephrin Type A receptor 2 (EPHA2 Produkte)
- Synonyme
- ARCC2 antikoerper, CTPA antikoerper, CTPP1 antikoerper, CTRCT6 antikoerper, ECK antikoerper, epha2 antikoerper, MGC89505 antikoerper, AW545284 antikoerper, Eck antikoerper, Myk2 antikoerper, Sek-2 antikoerper, Sek2 antikoerper, id:ibd5152 antikoerper, rtk6 antikoerper, G42 antikoerper, XE10 antikoerper, epha2-A antikoerper, EPH receptor A2 antikoerper, Eph receptor A2 antikoerper, epoxide hydrolase antikoerper, eph receptor A2 a antikoerper, EPH receptor A2 L homeolog antikoerper, EPHA2 antikoerper, Epha2 antikoerper, epha2 antikoerper, ephA2 antikoerper, epha2a antikoerper, epha2.L antikoerper
- Hintergrund
- EphA2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK
- UniProt
- P29317
- Pathways
- RTK Signalweg
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