Rekombinanter TNF alpha (Humicade Biosimilar) Antikörper
Der Human Monoklonal Anti--Antikörper wurde für ELISA validiert. Er ist geeignet, in Proben von Human zu detektieren.
Kurzübersicht für Rekombinanter TNF alpha (Humicade Biosimilar) Antikörper (ABIN5668143)
Target
TNF alpha (Humicade Biosimilar)
Antikörpertyp
Recombinant Antibody
Reaktivität
Human
Wirt
Human
Klonalität
Monoklonal
Konjugat
Unkonjugiert
Applikation
ELISA
Klon
CDP 571
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Verwendungszweck
- Anti-TNF alpha [CDP 571 (Humicade)], Human IgG4, kappa
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Spezifität
- The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
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Produktmerkmale
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Original Species of Ab: Human
Original Format of Ab: IgG4
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Aufreinigung
- Protein A affinity purified
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Reinheit
- > 98 % as determined by SDS-PAGE
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Endotoxin-Niveau
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
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Immunogen
- Human TNF-alpha
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Isotyp
- IgG4 kappa
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Applikationshinweise
- The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
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Kommentare
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NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TNF alpha (Humicade Biosimilar)
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Substanzklasse
- Biosimilar
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Hintergrund
- TNFA, Tumour necrosis factor superfamily member 2, TNFSF2
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UniProt
- P01375
Target
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