Rekombinanter TNF alpha (Humicade Biosimilar) Antikörper
Kurzübersicht für Rekombinanter TNF alpha (Humicade Biosimilar) Antikörper (ABIN5668144)
Target
Antikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
-
-
Verwendungszweck
- Anti-TNF alpha [CDP 571 (Humicade)], Rabbit IgG, kappa
-
Spezifität
-
The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
Application Notes original Clone: The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
-
Produktmerkmale
- NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
-
Aufreinigung
- Protein A affinity purified
-
Reinheit
- > 98 % as determined by SDS-PAGE
-
Endotoxin-Niveau
- Endotoxin is < 1.0 EU/mg as determined by the LAL method
-
Immunogen
- Human TNF-alpha
-
Isotyp
- IgG, kappa
-
-
anti-TNF alpha (Humicade Biosimilar) antibody
Reaktivität: Human ELISA, Neut Wirt: Human Monoclonal CDP 571 unconjugated Recombinant Antibody
-
-
Applikationshinweise
- Optimal working dilution should be determined by the investigator.
-
Kommentare
-
OriginalSpeciesName: Human
OriginalFormat: IgG4
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Konzentration
- 1 mg/mL
-
Buffer
- PBS with 0.02 % Proclin 300.
-
Konservierungsmittel
- ProClin
-
Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C,-20 °C
-
Informationen zur Lagerung
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
-
-
- TNF alpha (Humicade Biosimilar)
-
Substanzklasse
- Biosimilar
-
Hintergrund
- TNFA, Tumour necrosis factor superfamily member 2, TNFSF2
-
UniProt
- P01375
Target
-
