Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper

Produktnummer ABIN5668046

Dieses Anti-CD40L (Ruplizumab Biosimilar)-Antikörper ist ein Human Monoklonal-Antikörper zur Detektion von CD40L (Ruplizumab Biosimilar) in FACS, WB und BR. Geeignet für Human.

Kurzübersicht für Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper (ABIN5668046)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser CD40L (Ruplizumab Biosimilar) Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Blocking Reagent (BR)

Klon: Hu5c8

Produktdetails anti-CD40L (Ruplizumab Biosimilar) Antikörper

Verwendungszweck: Anti-CD40L [hu5c8 (Ruplizumab)], Human IgG1, kappa

Spezifität: The antibody binds to CD40L with an IC50 of 0.845 μg/mL.

Produktmerkmale:

Original Species of Ab: Human

Original Format of Ab: IgG1

Aufreinigung: Protein A affinity purified

Reinheit: > 98 % as determined by SDS-PAGE

Endotoxin-Niveau: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: Human CD40L

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531 ± 155 hours.

Kommentare:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu CD40L (Ruplizumab Biosimilar)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Andere Bezeichnung: CD40L (Ruplizumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: CD154, CD40 ligand, tumour necrosis factor ligand superfamily member 5, TNFSF5, tumour necrosis factor related activation protein, TRAP

UniProt: P29965