Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper

Produktnummer ABIN5564228

Dieser Human Monoklonal Antikörper detektiert spezifisch CD40L (Ruplizumab Biosimilar) in FACS, WB und Func. Es zeigt Reaktivität gegenüber Proben von Human und Hund.

Kurzübersicht für Rekombinanter CD40L (Ruplizumab Biosimilar) Antikörper (ABIN5564228)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Hund

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser CD40L (Ruplizumab Biosimilar) Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Functional Studies (Func)

Klon: Hu5c8

Produktdetails anti-CD40L (Ruplizumab Biosimilar) Antikörper

Verwendungszweck: anti-CD40L (human), mAb (rec.) (blocking) (hu5c8) (preservative free)

Spezifität: Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL. Cross-reacts with canine CD40L.

Kreuzreaktivität (Details): Cross-reacts with canine CD40L.

Produktmerkmale: Recombinant Antibody. Recognizes and binds human CD40L with an IC50 of 0.845 μg/mL. Cross-reacts with canine CD40L. Species cross-reactivity: Dog, Human. Clone: hu5c8. Isotype: Human IgG1kappa. Applications: FACS, FUNC, FUNC (Blocking), WB. Host: . Liquid. In PBS. CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.001EU/μg

Immunogen: Recombinant human CD40L.

Isotyp: IgG1 kappa

Anwendungsinformationen

Kommentare:

This antibody is a biosimilar called Ruplizumab (Antova, BG9588) and originally developed by Biogen. Ruplizumab is a CD40 ligand blocker designed for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis, but withdrawn from clinical trials due to side effects.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS.

Konservierungsmittel: Without preservative

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 3 months after receipt when stored at +4°C.

Haltbarkeit: 12 months

Details zu CD40L (Ruplizumab Biosimilar)

Target: CD40L (Ruplizumab Biosimilar) (CD40LG (Ruplizumab Biosimilar))

Andere Bezeichnung: CD40L (Ruplizumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund:

Alternate Names/Synonyms: CD40 Ligand, CD154, Tumor Necrosis Factor Ligand Superfamily Member 5,TNFSF5, Gp39, TRAP

Product Description: CD40 Ligand (CD40L), renamed TNFSF5 but now also known as CD154, TRAP and gp39, is a 34-39 kDa type II transmembrane glycoprotein, that belongs to the TNF superfamily, and a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. CD40L binds to CD40, which is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells. CD40L levels are increased in serum and in inflamed tissues of patients with autoimmune diseases.

UniProt: P29965