Ubiquilin 2 Antikörper (AA 555-624)

Produktnummer ABIN565449

Dieses Anti-Ubiquilin 2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Ubiquilin 2 in WB, ELISA und IF. Geeignet für Human. Dieses Primary Antibody wurde in 11+ Publikationen zitiert.

Kurzübersicht für Ubiquilin 2 Antikörper (AA 555-624) (ABIN565449)

Target: Ubiquilin 2 (UBQLN2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Ubiquilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Klon: 5F5

Produktdetails anti-Ubiquilin 2 Antikörper

Bindungsspezifität: AA 555-624

Verwendungszweck: Mouse monoclonal antibody raised against a partial recombinant UBQLN2.

Sequenz: PNQQFIQQMV QALAGANAPQ LPNPEVRFQQ QLEQLNAMGF LNREANLQAL IATGGDINAA IERLLGSQPS

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Antibody Reactive Against Recombinant Protein.

Immunogen: UBQLN2 (NP_038472, 555 a.a. ~ 624 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: In 1x PBS, pH 7.4

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-Ubiquilin 2 Antikörper (ABIN565449)

Riku, Watanabe, Yoshida, Mimuro, Iwasaki, Masuda, Ishigaki, Katsuno, Sobue: "Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis." in: Journal of neuropathology and experimental neurology, (2016) (PubMed).

Porta, Kwong, Trojanowski, Lee: "Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases." in: Journal of neuropathology and experimental neurology, Vol. 74, Issue 4, pp. 380-7, (2015) (PubMed).

Zeng, Wang, Merillat, N Minakawa, Perkins, Ramani, Tallaksen-Greene, Costa, Albin, Paulson: "Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3." in: Neurobiology of disease, Vol. 82, pp. 281-8, (2015) (PubMed).

Satoh, Tabunoki, Ishida, Saito, Arima: "Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains." in: Neuropathology and applied neurobiology, Vol. 39, Issue 7, pp. 817-30, (2014) (PubMed).

Riku, Watanabe, Yoshida, Tatsumi, Mimuro, Iwasaki, Katsuno, Iguchi, Masuda, Senda, Ishigaki, Udagawa, Sobue: "Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis." in: JAMA neurology, Vol. 71, Issue 2, pp. 172-9, (2014) (PubMed).

Farg, Sundaramoorthy, Sultana, Yang, Atkinson, Levina, Halloran, Gleeson, Blair, Soo, King, Atkin: "C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking." in: Human molecular genetics, Vol. 23, Issue 13, pp. 3579-95, (2014) (PubMed).

Konno, Tada, Shiga, Tsujino, Eguchi, Masuda-Suzukake, Hasegawa, Nishizawa, Onodera, Kakita, Takahashi: "C9ORF72 repeat-associated non-ATG-translated polypeptides are distributed independently of TDP-43 in a Japanese patient with c9ALS." in: Neuropathology and applied neurobiology, Vol. 40, Issue 6, pp. 783-8, (2014) (PubMed).

Bieniek, Murray, Rutherford, Castanedes-Casey, DeJesus-Hernandez, Liesinger, Baker, Boylan, Rademakers, Dickson: "Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion." in: Acta neuropathologica, Vol. 125, Issue 2, pp. 289-302, (2013) (PubMed).

Murray, Bieniek, Banks Greenberg, DeJesus-Hernandez, Rutherford, van Blitterswijk, Niemantsverdriet, Ash, Gendron, Kouri, Baker, Goodman, Petrucelli, Rademakers, Dickson: "Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72." in: Acta neuropathologica, Vol. 126, Issue 4, pp. 545-54, (2013) (PubMed).

Brettschneider, Van Deerlin, Robinson, Kwong, Lee, Ali, Safren, Monteiro, Toledo, Elman, McCluskey, Irwin, Grossman, Molina-Porcel, Lee, Trojanowski: "Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion." in: Acta neuropathologica, Vol. 123, Issue 6, pp. 825-39, (2012) (PubMed).

Al-Sarraj, King, Troakes, Smith, Maekawa, Bodi, Rogelj, Al-Chalabi, Hortobágyi, Shaw: "p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS." in: Acta neuropathologica, Vol. 122, Issue 6, pp. 691-702, (2011) (PubMed).

Details zu Ubiquilin 2

Target: Ubiquilin 2 (UBQLN2)

Andere Bezeichnung: UBQLN2

Hintergrund: Full Gene Name: ubiquilin 2
Synonyms: CHAP1,CHAP1/DSK2,Dsk2,HRIHFB2157,LIC-2,N4BP4,PLIC-2,PLIC2,RIHFB2157

Gen-ID: 29978

NCBI Accession: NM_013444